Amino Acids
Amino acids are vital for all living beings to build proteins. Amino acids and proteins are the building blocks of life.
In addition to processing feed materials into absorbable nutrients and excreting waste products of digestion, the GIT prevents the entry of harmful substances and potential pathogens into the bloodstream. Microbiome research has clearly shown that the interactions between the pig and its intestinal bacterial pool depend not only on the host, but also on the entire microbiome, i.e. the microbiota and the associated bacterial metabolites.
These metabolites affect a pig and contribute to its metabolism, influencing health, welfare and productivity. Beneficial interplay between host and microbiome is critical for maintaining host nutritional and immunological functions, while disease is often associated with microbial dysbiosis. In pigs, microbial dysbiosis is one of the causes of post-weaning diarrhoea, which globally still requires intensive use of antibiotics in animal husbandry1.
It is common practice to wean piglets at up to 28 days of age, however this is often a trigger for so-called post-weaning diarrhoea or post-weaning stress syndrome. Stress-induced eating depression is followed by excessive compensatory eating (overeating) after a few days. The social stress, the change of nutrition from milk to solid feed and the fluctuations in the filling of the digestive tract lead to intestinal dysbiosis (excessive growth of proteolytic bacteria such as E. coli and Clostridiodes, including numerous pathogenic strains) with the consequence of sometimes serious diarrhoea symptoms in the first weeks after weaning.
As a result, even today it is the weaners receiving the most antibiotics in pig production. In addition, the use of antibiotics in the different age categories is significantly associated with each other. This means that piglets from farms with high antibiotic use also need more antibiotics later as fattening pigs2. This leads to cost increases at the production level. Among global health problems, antimicrobial resistance resulting from the overuse of antibiotics is the one that the WHO addresses in its One Health approach.
There are numerous nutritional alternatives to counteract these issues. The principle of "maternal imprinting" and the feeding of pre-starter (creep) feed already in the suckling pen aim at minimising feed aversion in the weaning pen and ensuring a constant feed intake.
The strategy of crude protein reduction aims to prevent weaning piglets from colonic dysbiosis caused by undigested protein and has additional benefits such as emission reduction. Important with feeding low-protein diets is the targeted supplementation of limiting amino acids according to the ideal protein of pigs and in consideration of the raw materials used. Using synthetic amino acids is the tool to adapt the amino acid profile accurately.
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1Wessels, A. G. (2022). Influence of the gut microbiome on feed intake of farm animals. Microorganisms, 10(7), 1305.
2 Dewulf, J., Joosten, P., Chantziaras, I., Bernaerdt, E., Vanderhaeghen, W., Postma, M., & Maes, D. (2022). Antibiotic use in European pig production: less is more. Antibiotics, 11(11), 1493.